Early Signs of Alzheimer’s Disease

Startling Discovery: Young Diabetics Show Early Signs of Alzheimer’s Disease**

A recent study from the University of Colorado Anschutz Medical Campus reveals an alarming connection between youth-onset diabetes and an increased risk of Alzheimer’s disease (AD) later in life. This finding highlights the need for early monitoring and possibly cognitive testing for young individuals with diabetes.

Key Findings of the Study

Youth-Onset Diabetes and Alzheimer's Risk:** Researchers found that young people diagnosed with diabetes (both type 1 and type 2) exhibited early signs of Alzheimer’s disease, including abnormal blood biomarkers and brain changes associated with neurodegeneration.

Study Details:** Published in the journal *Endocrines*, the study examined approximately 80 young adults with diabetes, utilizing blood tests and PET scans to identify early signs of Alzheimer’s. The results raised concerns about the long-term effects of diabetes, especially considering the rising obesity rates among youth.

Increased Amyloid Proteins

Young individuals with diabetes showed elevated levels of amyloid proteins in the brain, a key feature of Alzheimer's disease. These proteins accumulate in brain regions typically impacted by Alzheimer’s.

Study Methodology

- **Participants:** The study included individuals with both type 1 and type 2 diabetes, comparing them to a control group without diabetes.

- **Research Tools:** Scientists employed blood biomarkers and PET scans to detect early signs of neurodegeneration. The participants were part of the SEARCH for Diabetes in Youth Study, a significant cohort that monitors diabetes in young people.

Concerns About Rising Obesity and Diabetes Rates

- **Obesity and Diabetes in Youth:** Approximately 20% of young people in the U.S. are obese, which raises their risk of developing diabetes. Obesity contributes to inflammation, leading to various health issues, including Alzheimer’s disease.

- **Rising Health Issues:** Dr. Allison Shapiro, the study's lead author, warns that young people are now exhibiting signs of aging-related diseases, such as Alzheimer’s, due to the obesity epidemic and the earlier onset of diabetes.

Future Research and Clinical Implications

- **Ongoing Studies:** Researchers plan to continue following these participants as they age to better understand how youth-onset diabetes contributes to the risk of Alzheimer’s. They are pursuing additional funding for long-term research.

Importance of Cognitive Testing

Dr. Shapiro suggests that cognitive testing, commonly recommended for older adults with diabetes, should also be considered for younger individuals with youth-onset diabetes. Early cognitive assessments could help healthcare providers monitor and address potential issues before they worsen.

This groundbreaking study indicates that diabetes diagnosed in childhood or adolescence may lead young people toward early-onset Alzheimer's disease. As childhood obesity and diabetes rates continue to rise, the urgency for preventive care and early cognitive testing is becoming increasingly critical.

Reference

Shapiro, A. L. B., et al. (2024). Biomarkers of Neurodegeneration and Alzheimer’s Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study. *Endocrines*. DOI: 10.3390/endocrines5020014ation and Alzheimer’s Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study. *Endocrines*. DOI: 10.3390/endocrines5020014

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